What other drugs will affect Sentinel: While Sentinel is safe to use in dogs at risk for MDRI-allele mutation (Australian Shepherds, Collies, Shelties,etc.), unless tested normal, caution is advised if the pet is also being given amiodarone (Cordarone), azole antifungals such as ketoconazole, carvedilol (Coreg), cyclosporine (Atopica), diltiazem (Cardizem), erthromycin (Ery-Tabs) or clarithromycin (Biaxin), quinidine, spironolactone (Adlactone), tamoxifen, and verapamil (Calan). If these or other symptoms develop contact your veterinarian. What are the possible side effects of Sentinel: Side effects of Sentinel are rare although some animals may exhibit depression, drowsiness, vomiting, itching, hives, loss of appetite, diarrhea, hypersalivation, seizures, and weakness. To prevent reinfection, daily cleanup of stools is recommended. It is also important to eliminate fleas on your pet and in the household and to not feed your pet rodents or uncooked meat or fish. What should I avoid while giving Sentinel to my pet: Because humans can contract hookworms and roundworms from animals, it is important to maintain good personal hygiene. Symptoms of overdose may include depression, drowsiness, vomiting, loss of appetite, diarrhea, hypersalivation, seizures, and weakness. What happens if I overdose the pet: Seek emergency veterinary medical treatment. Do not give a double dose of the medication. What happens if I miss giving a dose: Give the missed dose as soon as you remember. Consult your veterinarian for pregnant or lactating dogs. Keep this medication away from children and pets. Do not remove the tablet from its wrapper until ready to give the medicine. If your pet is off Sentinel for 6 months or less, re-start the medication and test after 6 months since microfilaria, that take 6 months to mature, will result in a positive test result. Heartworm testing should be performed prior to the start of prevention therapy. For dogs over 100 pounds give the appropriate combination of tablets. The usual dose of Sentinel for dogs 2 to 10 pounds is 2.3mg/46mg, 11 to 25 pounds is 5.75mg/115mg, 26 to 50 pounds is 11.5mg/230mg and 51 to 100 pounds is 23mg/460mg given once a month year-round. If you do not understand the directions ask your pharmacist or veterinarian to explain them to you. How should this medication be given: Give Sentinel exactly as directed by the veterinarian. What should I discuss with my veterinarian before giving Sentinel to my pet: Tell your veterinarian if your pet has ever had an allergic reaction to the medication. Sentinel may also be used for purposes other than those listed in this guide. The American Heartworm Society recommends that heartworm prevention be used year-round. Sentinel is also used to control fleas by preventing the development of flea eggs. Sentinel also protects against hookworms, roundworms, and whipworms. What is Sentinel: Sentinel is given once a month for the prevention of heartworm disease in dogs. This medication should be given once a month year-round. Sentinel is available as artificial beef flavored (derived from pork and soy protein) chewable tablets. What is the most important information I should know about Sentinel: Sentinel is a medication FDA-approved for use in dogs.
Milbemycin Oxime (mil’-beh-my’-sin ox’-eem) and Lufenuron (lew-fen’-your-on) To prevent re-infection, clean up stools on a daily basis. Its also important to eliminate fleas and to not feed your pet uncooked meat or fish. Its important to maintain good personal hygiene, since humans can contract hookworms and roundworms. Side effects are rare, though some animals may exhibit depression, drowsiness, vomiting, itching, hives, loss of appetite, diarrhea, or seizures.
Sentinel may be given along with Capstar, which treats flea infestation. Lufenuron prevents most flea eggs from hatching or maturing into adults and thus prevents and controls flea populations by breaking the life cycle. Lufenuron, the other active ingredient, is an insect development inhibitor that breaks the flea life cycle by inhibiting egg development. Milbemycin oxime eliminates the tissue stage of heartworm larvae and the adult stage of hookworm, roundworm, and whipworm infestations. Sentinel is the only monthly oral preventive that guards against heartworms, adult roundworms, adult hookworms, whipworms, and prevents the development of flea eggs. Sentinel Spectrum Medium Dogs 26-50 lbs (11-22 kg) Chews 3 Pack
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